Sentence examples for binding domain which may from inspiring English sources

One speculation was that this was because LEDGF/p75 contains an A/T hook DNA binding domain, which may promote integration in A/T-rich regions in LEDGF/p75-positive cells [40]. Figure 4C shows that in the SupT1 cell model as well, strong depletion of LEDGF/p75 resulted in increased G/C content at integration sites (P = 0.0003 by regression analysis).

Ligatoxin B has a DNA binding domain, which may be related to the inhibition of nucleic acid and protein synthesis [ 28].

Our results suggest that reversible phosphorylation may also regulate a non-catalytic function of PTEN, its ability to interact with regulatory proteins via its C-terminal PDZ-binding domain, which may control its localization, stability and activity [ 7].

These proteins have an average Ser+Thr equal to 13.8% of their total aa, as opposed to 0.9% observed as the average of all proteins found in Additional File 2. We additionally report on a polypeptide (AE-466, mucin-like peritrophin) containing three glycosylation sites and one chitin-binding domain, which may be involved in proximal lining of the cuticular duct.

In an in silico protein analysis, a protein domain of OppA was found to be similar to an extracellular peptide-binding domain, which may be related to the capture of peptides from the extracytoplasmic environment and the transfer of these peptides to the transmembrane channel-forming proteins.

Many endocrine disruptors may affect the transcriptional activity of nuclear receptors by changing the action of competitively binding with ligand biding domain, which may modify coactivator activity and dissociate corepressors that reduce deacetylases action.

The inactive catalytic domain of HD-PTP could therefore act as a phospho-tyrosine binding module, also called STYX domain, which may control cell signaling pathways by preventing the dephosphorylation of its binding partners or by regulating their cellular localization [27], [33].

SIX1 encodes a protein characterized by a divergent DNA-binding homeo-domain and an upstream SIX domain, which may be involved in determining DNA-binding specificity and protein protein interactions.

A homologue from Ichthyophthirius has a Brix domain which may be important for binding single-stranded RNA [ 54].

ADAMTS-5 contains 86 basic residues, as well as an XBBXBX motif (NKKSKG) in the Sp domain, which may constitute the glycosaminoglycan-binding residues of this domain.

The NAC family transcription factors are highly conserved at the N-terminal NAC binding domain and have a highly variable C-terminal domain, which may function as a transcriptional activator or repressor (Olsen et al., 2005).