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Calmodulin dependent protein kinase I (299 320) binding domain, which is a putative CaM-binding region, was obtained from AnaSpec.
Residues 1 150 form the NADPH binding domain, which is a variant of the typical dinucleotide-binding fold.
Almost all enzymes that degrade insoluble substrates contain a substrate binding domain, which is usually joined to the catalytic domain (CBM) (Wilson. 2011).
GATA proteins share a highly homologous zinc finger DNA binding domain which is also highly conserved from invertebrates to mammals [1].
However, the location of the binding sites can only be confirmed from crystal structures of DNA-TLR9 binding domain, which is beyond the scope of our study.
Similar genes are associated with the putative tetrachloroethene RDase gene of G. lovleyi strain SZ and a putative RDase gene of D. hafniense strain DCB2; however, the genes of the latter two bacteria include an FMN binding domain, which is absent in strain 2CP-C (Figure S4) [72].
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First, DBD method [ 20] aimed to collect all the proteins containing DNA binding domain, which are sometimes not necessarily involved in the regulation of gene expression, such as transposase, integrase, recombinase, or methyltransferase.
Glycosylation of LDL apo B (the surface protein of LDL) occurs mainly on a positively charged lysine residues within the putative LDL receptor binding domain which are essential for the specific recognition of LDL by the LDL receptor [ 20].
In general, transcription factors functionally result from some important conserved motifs within and outside the DNA binding domain which are related to transcriptional activity, nuclear localization, and protein-protein interactions [ 31].
GCV-MP binds as GMP to the GMP-binding domain, which is identical in E. coli and human GMPKs, but unlike the natural substrate fails to stabilize the closed, catalytically-competent conformation of this domain.
Cdc42 cycling is modulated by ARHGAP10, a Rho GTPase- activating-protein (GAP) that also harbours an Arf-binding domain which is specific for Arf-GTP (ABD; [10], [11]).
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