Sentence examples for binding domain which consists from inspiring English sources
Egr-1 regulates gene transcription by the specific binding of its DNA binding domain, which consists of three zinc fingers, to the consensus GC-rich regions in the promoter of its target genes [11].
Each finger of the DNA binding domain, which consists of tandem Cys-His2 arrays, recognizes approximately three bp of DNA.
The recognition of MDP leads to a recruitment of the protein kinase RIP2/RICK to the N-terminal effector binding domain, which consists of two adjacent caspase-recruitment domains (CARDs).
157 Bazedoxifene design differed from its predecessors in its core binding domain, which consists of a 2-phenyl-3-methyl indole, a side chain effector region connected to the core binding region via a methylene hinge, and a hexamethylenediamine ring at the side chain terminus.
Our modeling revealed that the enzymatic core is formed by a twisted, six-stranded β-sheet flanked by six helices (α1-α6) linked through a loop region to the cell wall binding domain which consists of two anti-parallel β-sheets.
Exons 2 6 encode the ligand-binding domain, which consists of seven tandem repeats of 40 amino acids each.
A multiple alignment of some stress-NAC TFs [ 15] by DNAMAN revealed that CiNAC3 and CiNAC4 shared a highly conserved N terminal DNA binding domain, named NAC domain which consists of 5 consensus sub-domains, and a highly variable C-terminal transcriptional regulation domain (Fig. 1).
To develop chemical probes that selectively target Stat3, we virtually screened 920,000 small drug-like compounds by docking each into the peptide-binding pocket of the Stat3 SH2 domain, which consists of three sites the pY-residue binding site, the +3 residue-binding site and a hydrophobic binding site, which served as a selectivity filter.
Similar to HA, the receptor-binding region is located at the top of the head domain, which consists only of HEF1 residues.
The AP2/ERF superfamily is a large gene family of transcription factors and is defined by the AP2/ERF domain, which consists of 60~70 amino acids involved in DNA binding.
