Sentence examples for binding domain which can from inspiring English sources

The resulting DNA methylation can be recognized by MECP2, a protein containing a MBD (methyl binding domain) which can also bind to and recruit SUV3-9 enzymes to pericentric heterochromain 119 (Fig 6A).

The concept of bottom-up synthetic epigenetics (epigenetic editing) relies on the combination of an artificial DNA binding domain, which can directly bind a unique sequence found within the desired locus, with an effector domain able to edit the epigenetic state of that locus.

Lactobacillus S-layer proteins differ from those of other bacteria in their smaller size and high predicted p I. The positive charge in Lactobacillus S-layer proteins is concentrated in the more conserved cell wall binding domain, which can be either N- or C-terminal depending on the species.

The structure of Ssa1p contains two distinct domains, the nucleotide-binding domain (NBD) that is responsible for binding and hydrolyzing ATP and the substrate-binding domain which can bind short hydrophobic segments of incompletely folded or unfolded polypeptides, in order to prevent adverse aggregation [ 63].

They consist of a central DNA-binding domain that directs the receptor to specific DNA sequences within a gene promoter, and a ligand-binding domain, which can accommodate a variety of different compounds.

The zinc-finger nucleases (ZFNs) are engineered endonucleases composed of a tandem array of zinc finger DNA-binding domains, which can be designed to selectively bind a DNA sequence of choice, coupled to the catalytic domain from the type IIS restriction enzyme FokI.

With the DNA cleavage action itself showing no sequence preference, the specificity of ZFN and TALEN is determined by their DNA-binding domains, which can be engineered to recognize specific sequence in the gene of interest.

Fluorescence quenching of about 50% was observed at 520 nm adding the DNA binding IHF domain which can be correlated to a fluorophore distance of 51 Å in accordance to the crystal structure (Rice et al. 1996; Lorenz et al. 1999).

Here, we systematically examined the complex crystal structures of PTPN4 PDZ domain with its known peptide ligands; a number of charged amino acid residues were identified in these ligands and in the peptide-binding pocket of PDZ domain, which can constitute a complicated salt-bridge network across the complex interface.

In contrast to transition state mimicking inhibitors, it does not interact with the enzyme's C-terminal domain, which can be beneficial for ligand binding.

These receptors have a cytoplasmic TK domain which can be activated by ligand binding, followed by dimerization.