The constant exons encode a highly conserved donor-binding domain, which binds the UDP-glucuronic acid (UDPGA), and the carboxyl-terminal endoplasmic-reticulum ER -anchoring transmendoplasmic-reticulum ER -anchoring
Residues 94 292 form the DNA-binding domain, which binds DNA in a sequence-specific manner and is also referred to as the core domain.
FOXG1 contains a highly conserved DNA-binding domain, which binds to specific DNA sequences and regulates gene expression (Yao et al, 2001).
SRs are a class of ligand-activated TFs; they include a ligand-binding domain which activates gene expression in the presence of specific sex or adrenal steroid hormones and a DNA-binding domain, which binds as a dimer to palindromic REs consisting of two half-sites each six bases long (Bentley, 1998; Bain et al., 2007).
The Ets TF (transcription factor) family is found throughout the metazoa, comprising 28 members in humans [ 1, 2], all containing the evolutionarily conserved DNA-binding Ets domain which binds the invariant DNA sequence 5′-GGA(A/T -3′ [ 2].
For instance MerR family members contain MerR DNA-binding and B12-binding domains (a protein domain which binds to cobalamin (vitamin B12)).
Ets transcription factors are identified by a highly conserved DNA binding domain (the ets domain), which binds to sites containing a central GGA motif [ 83].
In addition, p47 phox possesses another membrane-binding region, the PX domain, which binds to the headgroups of phosphatidylinositols present in the membrane [ 23- 25].
ZFP36 belongs to the TIS11/TTP protein family, a class of mRNA binding proteins carrying a conserved zinc finger domain, which binds to AU-rich elements in the 3′UTR of mRNAs.
In this study, a fusion protein was generated by the union of two cell wall-binding domains, i.e., the Lysin Motif (LysM) domain, which binds to bacterial cell walls, and the pseudomurein cell wall-binding (PMB) domain, which binds to pseudomurein-containing archaeal cell walls.
