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First, DBD method [ 20] aimed to collect all the proteins containing DNA binding domain, which are sometimes not necessarily involved in the regulation of gene expression, such as transposase, integrase, recombinase, or methyltransferase.
Glycosylation of LDL apo B (the surface protein of LDL) occurs mainly on a positively charged lysine residues within the putative LDL receptor binding domain which are essential for the specific recognition of LDL by the LDL receptor [ 20].
In general, transcription factors functionally result from some important conserved motifs within and outside the DNA binding domain which are related to transcriptional activity, nuclear localization, and protein-protein interactions [ 31].
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He added a DNA binding domain, which is slightly different than the native ecdysone domain.
Residues 1 150 form the NADPH binding domain, which is a variant of the typical dinucleotide-binding fold.
However, the protein domains within Dp140 largely overlap with those of the other dystrophin isoforms (with the exception of the N-terminal/actin binding domain which is specific to full length dystrophin).
Calmodulin dependent protein kinase I (299 320) binding domain, which is a putative CaM-binding region, was obtained from AnaSpec.
Almost all enzymes that degrade insoluble substrates contain a substrate binding domain, which is usually joined to the catalytic domain (CBM) (Wilson. 2011).
However, the location of the binding sites can only be confirmed from crystal structures of DNA-TLR9 binding domain, which is beyond the scope of our study.
GATA proteins share a highly homologous zinc finger DNA binding domain which is also highly conserved from invertebrates to mammals [1].
Spectrin's F-actin binding domain, which is composed of a tandem pair of CH domains located at the N-termini of each beta chain, was modeled using the crystal structure of the homologous domain from alpha-actinin (PDB ID: 2EYI) [83].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com