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No binding to BiP substrate binding domain was observed.
Conversely, for DMPs that decreased their methylation level, an enrichment for the ETS family binding domain was observed (Fig. 3 and Table S11).
In the case of MSV, a nucleotide site within the portion of the rep gene encoding the retinoblastoma-related protein binding domain was observed to rapidly and repeatedly mutate from an atypical MSV-A polymorphism to one that is conserved in all known field isolated MSV genomes [ 64, 65].
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A mixture of 3R and 4R binding domains is observed in intracellular neurofibrillary tangles in DNTC [ 45], although extracellular tangles (ghost tangles) are predominantly 3R tau (Fig. 4).
In HarmiGluR family with the exception of HarmiGluR1 and 5, a conserved amino acid profile in three key residues of ligand-binding domains was observed (arginine, threonine and aspartate/glutamate).
Correspondingly, no Ca2+ binding to this site of the C2B domain was observed in the recently determined crystal structure of a synaptotagmin-3 C2AB fragment [47] (Figure 5D).
Direct binding of EMD 57033 to the motor domain was observed for Dictyostelium discoideum (Dd) myosin-2 and myosin-5 motor domain constructs but not for Dd myosin-1B, Dd myosin-1C, Dd myosin-1D, and Dd myosin-1E motor domain constructs.
No change in the Tbr1-positive domain was observed.
Conversely, a lack of hits for conserved DNA binding domains including homeodomains, MADS, bZip, bHLH and GATA fingers, and FKH domains was observed in the genome [ 26].
Here domain I, the NADH binding domain, was used as an ankerpoint as no structural rearrangements where observed inside this domain.
As for exon10 SH3 domain binding, ionic strength-sensitive PRD SH3 domain binding was observed, albeit with lower binding affinity.
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