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Unexpectedly, the sequence Lys-Lys-Phe-Asn at positions 291-294, adjacentothethe CaM binding domain, was found to be sufficient to maintain an inhibited state in a truncated form of the kinase.
Among these a D222G mutation in the HA receptor binding domain was found in two of the eight Indian isolates obtained from fatal cases.
In contrast to the ligand binding domain of the LDLR, which consists of 7 tandemly arranged so-called binding repeats, the chicken receptor's binding domain was found to contain 8 such repeats.
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The C2CH zinc-coordinating THAP DNA binding domain is found in many animal genomes in >300 genes.
Corresponding serine (S457) and tyrosine (Y459) residues in the SH2 binding domain were found in DLC2.
In this heterodimer, the ligand binding domain is found only within the GABAB1 subunit while G protein activation is entirely mediated through the GABAB2 subunit.
The NAD(P H/NAD(P)+ binding domain is found in numerous dehydrogenases as well as in many other redox enzymes, but is rather unusual for a hydrolase.
However, in this study the ligand-binding domain was found to be dimeric rather than monomeric.
A cNMP-binding domain (cyclic nucleotide-monophosphate-binding domain) was found in all Acdp members.
One mutation (Pro47→Ala), in the highly conserved ATP-binding domain, was found to lead to destabilization of BACH1 protein.
In addition, a cNMP-binding domain was found in all Acdp proteins, which is usually present in ion channels and cNMP-dependent kinases [ 10- 13].
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