Evidence of a conserved DNA-binding domain was detected for 51.8% of the wheat sequences identified, i.e. 3,681 sequences (Table 1).
However, the exact role played by these single domain RRs needs further investigation.> While most of Azospirillum RRs with known output domains (64%% ± 1 %) contain a DNA-binding domain (39%% ± 2 %) and may serve as transcriptional regulators, no RNA-binding domain was detected among Azospirillum RRs, suggesting that no control of gene expression through antitermination is mediated by RRs.
Small zinc binding domains were detected by the presence of metal ions and proximal histidine and cysteine residues.
A total of 36 TP53 mutations, most commonly in the DNA-binding domain, were detected in 7% of patients.
A similar observation was noted for Cr VI -stressed S. oneidensis MR-1 Cr VI -stresseda DNA-binding reS.oneidensisator (designated SO2426), also of the OmpR/PhoB subfamily [ 46] of winged-helix DNA-binding domains, was detecellsat the protein level only in chromate-challenged cells [ 26, 27].
Proteins containing putative DNA-binding domains were detected by means of the HMM library and genome assignments server Superfamily version 1.75 [ 107].
The Soloist protein, coded by a single-copy gene and characterized by low conservation at the ERF DNA-binding domain, was detected in all higher plant genomes examined.
Frequent re-invention of analogous architectures involving functionally related, but not homologous, domains was detected, such as, fusion of different SMBDs to several types of DNA-binding domains to form diverse transcription regulators in prokaryotes and eukaryotes.
In one patient, a unique ESR1 transcript with a genomic insert encoding a premature stop codon and a truncated ESR1 protein lacking most of the estrogen binding domain was the only transcript detected.
Additionally, novel plant specific ZFP-associated domains were detected that may be involved in DNA binding or repressor functions.
