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The latter is a heparin binding domain that interacts with HSPGs [14].
A ligand binding domain that interacts with estradiol is also located in the AF-2 region [ 10, 11].
The N-terminal region is involved in transactivation and the core of the protein forms a DNA binding domain that interacts specifically with DNA target sequences.
The different effects of Ets-1 and Fli-1 on controlling CCN2 promoter activity is intriguing in light of the fact that approximately 25 human ETS proteins have been identified, all of which share a highly conserved DNA binding domain that interacts with the core DNA target GGAA/T [ 12, 13].
The toxin used in this report, CNF1, is produced by certain pathogenic strains of E. Coli and consists of a N-terminal binding domain that interacts with membrane receptors on target cells, a middle translocation domain to enter the cytosol and a C-terminal catalytic domain [ 22, 23].
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BESS domain is a protein binding domain that can interact each other or with other domains.
These comprise a REM-CDC25-H domain, which contains the catalytic or "GEF" domain, and a large proline-rich domain or SH3-binding (SH3-b) domain that interacts directly with Crk isoforms and other SH3-containing proteins such as p130Cas, Hck and c-Abl [ 1- 3].
The kinase domain of PSKR1 also contains a calmodulin binding domain that has been shown to interact with all isoforms of calmodulin and is essential for normal growth [ 17].
Each cohesin domain consists of a subunit-binding domain that interacts with a docking domain (dockerin) for each catalytic component of the cellulosomal enzyme (Cha et al. 2007).
HSC70 and HSP70 proteins comprise a peptide-binding domain that interacts with denatured polypeptides and a regulatory ATPase domain.
In addition, the γ-tubulin C terminus encodes a DNA-binding domain that interacts with E2F-regulated promoters, resulting in γ-tubulin-mediated transient activation of E2Fs.
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