Sentence examples for binding domain required for from inspiring English sources
The N-terminus ligand binding domain required for class C GPCR activation was present in seven of the putative GPCRs.
In gnathostomes Dacts 1,2,3, motif 11 g contains the K-L/V-MTTV sequence, a PDZ binding domain required for the interaction of Dact with Dvl [ 3- 5, 9].
We conditionally inhibited Wnt signaling via expression of a heat shock inducible variant of POP-1/TCF that lacks the N-terminal β-catenin binding domain required for activation of target gene expression (hs:: delNTpop-1).
Yeast two-hybrid analysis is based on the yeast transcription factor Gal4, which is split into two functional domains (an activating domain and a binding domain) required for binding DNA and activating transcription of target genes.
Shown in evolutionary analyses, the formation of the AKAP7-RI/RII binding domain (required for AKAP/PKA-R interaction) corresponds to vertebrate-specific gene duplication events in the PKA-RI/RII subunits.
Both Ectocarpus proteins have the ATP binding and the HEXXH metal binding domains required for activity [90].
Further, it has been shown that NEMO contains a K63-specific ubiquitin-binding domain, required for IL-1-mediated IKK activation, which mediates interaction with ubiquitinated IRAK-1, but not ubiquitinated TRAF6 [41], [41].
Alternatively, the reduction in starch degradation rate in the mex1 mutant might arise from multi-oligosaccharides inhibiting an enzyme involved in the attack on the starch granule, possibly by competing with granular starch for a starch-binding domain required for attack on the granule [ 1, 36].
These are composed of several domains including a leucine-rich repeat, important for PAMP/DAMP sensing, a nucleotide-binding domain required for oligomerisation, and a caspase activation and recruitment (CARD) and/or a PYD, for recruitment to caspase-1 directly, or via the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC), respectively.
