Current models suggest that the DNA-binding domains of one tail tail module bind adjacently to a single DNA segment in linear filaments, which form at <5 mM Mg2+, or contact separate DNAs or DNA segments in bridged filaments favored at >5 mM Mg2+ (Liu et al., 2010).
Based on the fact that angiocidin contains peptide domains homologous to the polyubiquitin binding domain of S5a, one of the major polyubiquitin recognition subunits of the proteasome, we speculated that the antitumour activity and apoptotic activity of angiocidin may in part be mediated by peptide regions of angiocidin that bind polyubiquitin.
A point mutation (hsp90.2-3 hsp90.2-3TP-binding domain of one of the constitutive cytosolic HSP90s, HSP90.2, renders the plant sensitive to pathogens [19].
Thus, the models neglect such details as whether each residue in the binding domain of the TF recognizes one or more DNA bases, as well as issues of DNA malleability, non-specific amino-acid base contacts, etc.
The binding domain of E is a multifunctional one since it can bind to both R domains.
The DNA binding domain of GAL4 is expressed in one pattern (CRM1-GAL4DBD), the activation domain of GAL4 is expressed in a second pattern (CRM2-GAL4AD), and only in the intersection of the two patterns does the reconstituted GAL4 protein drive expression of UAS transgenes.
Limited to the key functional domains as annotated on Figure 1 (which is derived from Williams et al. [ 4]), and excluding the second DNA binding domain of MRE11A, we observed 23 rMS and one final exon truncating variant that we evaluate as an in-frame deletion (RAD50 c.3852del4).
Side chains of several residues (101 110) from the structural zinc binding loop of the catalytic domain of one subunit also interact with residues (260 262) of the coenzyme binding domain of the other subunit in a dimer.
For instance, H1 binds to the H1 helix of the DNA binding domain of MYC.
