Sentence examples for binding domain of a from inspiring English sources
The receptor binding domain of a single HA monomer binds to sialylated glycans with very weak affinity, and strong avidity to host cell receptors is only achieved by polyvalent binding of multiple HA trimers [ 38, 39].
The Akt construct was created by fusing a conditionally active form of Akt containing a src myristoylation sequence to the hormone binding domain of a mutant ER that selectively binds 4-hydroxytamoxifen (4-HT) (24).
In principle, the introduction of multiple nucleobase amino acids into the nucleic acid binding domain of a protein should enable these modified proteins to interact with their nucleic acid substrates using Watson-Crick and other base pairing interactions.
This model is based on observing the retention behaviour of de novo designed model 18-residue amphipathic α-helical peptides (representing the hydrophobic binding domain of a ligand) on reversed-phase packings by varying hydrophobicity (representing a receptor protein with a hydrophobic binding pocket).
We have designed 18-residue amphipathic α-helical peptides (representing the hydrophobic binding domain of a ligand), where the non-polar face interacts with the non-polar face of a reversed-phase stationary phase (representing a receptor protein with a hydrophobic binding pocket).
It is well known that CART cells can specifically target tumor cells by expressing a chimeric antigen receptor (CAR) constructed with an extracellular binding domain of a single-chain fragment of the antibody variable region (scFv) and the intracellular signaling domains of CD3zeta, coupled with or without co-stimulatory molecules such as CD28 and CD137.
Using a set of point mutations, Johnson et al. (2005) located PtdIns(4,5 P2 binding site in the RAS binding domain of A-RAF.
The structural basis for binding of RNA to the argonaute protein was examined by X-ray crystallography of the binding domain of an RNA-bound argonaute protein.
The following orfs might be involved in immunity against the lantibiotic: BLi04120 is the ATP binding domain of an ABC transporter.
Ewing tumors, the second most frequent bone tumors in teenagers and young adults, show specific translocations fusing the 5' part of EWS to the 3' sequence encoding the DNA binding domain of an ETS factor [1], [2].
Why has BAG2 evolved to specifically bind mutant p53 and how can it discriminate between the DNA binding domains of a diverse range of mutant p53 s compared to wild type?
