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Interestingly, the defined Suppressor of Hairless binding domain is interrupted by a nonconserved spacer sequence and the N-terminal motif is sufficient for binding.
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Note that the large domain is interrupted by insertion of the small one, resulting in two linkers across the domain boundary.
In cas3, the coding region of the conserved domain is interrupted by an intron.
The resulting proteins are composed of two or more domains, and the linear sequence of one domain is interrupted by the insertion, forming discontinuous domains.
An interesting feature is that its velvet domain is interrupted by a 99 amino acids insertion (Ahmed et al. 2013).
Surprisingly, in teleost pcloa genes the core domain is interrupted with sequences that appear to represent a duplication of sequences present in the adjacent extended domain.
For example, in the Monocot II clade the CuA domain is interrupted by intron A4 immediately after the third conserved histidine residue in the FFPWH motif.
The EGF domains are interrupted by seven transforming growth factor (TGF -binding proTGF -binding characterized by 8 cysteine residues involved in intra-domain disulfide bonds (protein et al., 1993; Robinson et al., 2006).
These domains were interrupted in the Ulnaless mutation, a balanced inversion that modified the topography of the locus.
Previous studies suggest that protein functions could be affected if their functional domains are interrupted by AS [ 9– 17, 18] 18].
The series of FN type III domains are interrupted in both mouse and human tenascin-X by a proline-rich stretch of about 100 amino acids.
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