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In this heterodimer, the ligand binding domain is found only within the GABAB1 subunit while G protein activation is entirely mediated through the GABAB2 subunit.
The NAD(P H/NAD(P)+ binding domain is found in numerous dehydrogenases as well as in many other redox enzymes, but is rather unusual for a hydrolase.
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Corresponding serine (S457) and tyrosine (Y459) residues in the SH2 binding domain were found in DLC2.
Among these a D222G mutation in the HA receptor binding domain was found in two of the eight Indian isolates obtained from fatal cases.
In contrast to the ligand binding domain of the LDLR, which consists of 7 tandemly arranged so-called binding repeats, the chicken receptor's binding domain was found to contain 8 such repeats.
The SANT (SWI3, ADA2, N-CoR, and TFIIIB DNA-binding) domain is found in most of the plant KMT6A subclass proteins.
The Rossmann domain of CapE is located at the centre of the hexamer and mediates most of the inter-chain contacts, whereas the substrate-binding domain is found at the periphery of the complex.
Four domains showing typical features of fungal cellulose binding domains were found in the N-terminal and C-terminal ends of the protein.
More recently, two further putative CaM binding domains were found [18] using a peptide scanning approach, one in the N- (BD-N: AA 151 165) and another in the C-terminus (BD-C1: AA 674 683) of hEAG1.
Three of these putative SMTs that harboured variant sterol binding domains were found to conduct two successive methyl transfers onto linear triterpenoids.
For example, in one case where only one domain in a repetitive protein was isolated after a decrease in pH, additional binding domains were found when bacteria were added to the well (unpublished results).
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