Sentence examples for binding domain indicating that from inspiring English sources
Stimulation of elongation is also reduced by a mutation in the Npl3 RNA binding domain, indicating that RNA binding is important.
This defect was efficiently rescued by expressing Bach1 fragments that lack the DNA binding domain, indicating that its function in mitosis involves a transcription-independent mechanism.
In this study, we showed that 4-HNE could induce nuclear translocation of the NRF2 mutant lacking the KEAP1 binding domain, indicating that 4-HNE may have a direct effect on NRF2 itself.
In vivo studies of colon cancer xenografts expressing a β6-mutant lacking the ERK2 binding domain indicated that deletion of the β6-ERK2 binding motif greatly compromised tumor growth.
Transcripts encoding the pathogenesis-related PR1 and PR2 proteins were elevated in AtGRP7-ox plants but not in plants overexpressing AtGRP7 with a point mutation in the RNA-binding domain, indicating that the regulation involves RNA binding activity of AtGRP7.
Moreover, another pull-down experiment showed that S-labelled NO66 interacted with a segment of Osx (1 270) that contains the transactivation domain but lacks the DNA-binding domain, indicating that this Osx segment was sufficient for NO66 interactions.
Structural modeling of the FAD-binding domain of human COQ6 using Composer in Sybyl (Tripos, St Louis, MO) indicated that the H208 residue would clash with the residues S212 and V214 in the FAD-binding domain, indicating that H208 may negatively affect COQ6 function by interfering with its binding to FAD.
The role(s) of its intracellular mammalian ortholog is poorly understood, but a predicted phosphorylation site and a series of Ca2+ binding domains indicate that this protein could be involved in processes determining macrophage activity in immune response [ 76].
The analysis on the 3D structure of CSRP3 zinc-binding domain indicates that this bear-specific amino acid substitution in CSRP3 may have a significant impact on its structure.
