Sentence examples for binding domain in which from inspiring English sources

The bioinformatic SNP had to be validated in a multi-ethnic human cohort; 2. The putative nuclear receptor binding domain in which it is located had to bind a transcription factor; 3.The SNP had to alter binding of that transcription factor; and 4. The SNP had to change gene transcriptional activity.

In this report, we describe the preliminary evidence suggesting the presence of a drug-binding pocket within FOXM1 DNA binding domain, in which inhibitors fit to dissociate the protein-DNA complex.

The observations show a rather special structural properties of the DNA binding domain, in which the recognition helix h3 adopts a 310 helix and the center-to-center separation between recognition helices h3 and h3' is reduced from 34.9 Å to 30.4 Å upon inducer binding.

The conservation found in clade 1 eIF4E does not extend to the eIF4G binding domain, in which there are amino acid substitutions within each sub-clade that are likely to have strong affinities for different binding partners.

This analysis revealed that BH4-Bcl-2 acts as a discontinuous binding domain, in which every surface-accessible residue (Asp10, Arg12, Lys17, His20, Tyr21, Gln25, Arg26, Tyr28) contributed to the inhibition of IICR.

The principal isoforms differ in the domain responsible for oligomerization, but are identical through the transactivation and DNA binding domains in which many TP53 mutations occur.

The Nef/HCK interaction is mediated by an SH3 binding domain in Nef 72PQVPLR77 which may be too similar with cellular SH3 interaction.

Our analysis genetically underscores the significance of the F-actin binding domain in cytoskeletal remodeling, which is of importance for the major role of HS1 in apoptosis and for cortactin in cell migration.

Hsp70 consists of a N-terminal ATPase domain and a C-terminal peptide binding domain (PBD) in which there is EEVD motif enabling it to bind to co-chaperones and other heat shock proteins such as Hsp90, Hsp40 and Hop [25], [26], [27], [28].

Hsp70 could be divided into two functional domains, the N-terminal ATPase domain and the C-terminal protein binding domain (PBD) in which there was EEDV motif (Fig. 2E).

The two cellobiohydrolases investigated in this study are similar in amino acid sequence differing mainly by the presence of a cellulose-binding domain in Cbh1 which makes this enzyme a substrate bound and CelD a soluble substrate unbound enzyme.