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Remarkably, modeling and X-ray crystallography reveal non-secosteroidal hybrids bind in the VDR ligand binding domain in the opposite orientation of their secosteroidal counterparts.
These proteins have a single transmembrane region with a putative Ca(2+) binding domain in the lumen of the endoplasmic reticulum.
We identified 3 NAAIRS substitutions in Gα12 that completely abrogated binding, and identified a previously described 74 amino acid Gαi/o binding domain in the PC1 C-terminus as necessary for Gα12 interaction.
To determine if OsWRKY80 has transcriptional activation activity, we fused the full-length OsWRKY80 in frame to the GAL4 DNA binding domain in the pGBKT7 vector and transformed into yeast strain AH109.
The L1 binding domain in the mammalian mitochondrial 16S rRNA was found to be highly conserved [17].
It implies that RolR and its homologues may have the similar structural properties for DNA binding domain in the induced and non-induced status.
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Furthermore, these molecules can bind the RAR ligand-binding domain in the CoA-BAP system but not RXR ligand-binding domain.
However, it is not known if all three TAM receptors bind to both signaling proteins equally, and the importance of the phospholipid-binding domain in the signaling proteins remains unclear.
Alejo, A. et al. A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.
The increase in the hit number may result from elimination of the noise from the acceptor-binding domain in the BLAST search.
Strikingly, we identified the positively charged ribosome-binding domain in the N terminus of the betaNAC subunit (N-betaNAC) as a major chaperone entity of NAC.
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