Sentence examples for binding domain has been from inspiring English sources
That SKI-II is a SphK1 inhibitor and binds at the Sph binding pocket rather than the ATP binding domain has been unequivocally demonstrated by a co-crystal structure with SphK1 at 2.3 Å resolution.
By deleting the prephenate dehydrase domain, a functional chorismate mutase linked directly to the phenylalanine binding domain has been engineered and overexpressed.
In bacterial RNA polymerase, this motif, the zinc binding domain, has been implicated in protein DNA interactions that stabilize the transcription elongation complex and that occur downstream of the catalytic center.
The binding domain has been localized within the first exon of BCR and consists of at least two SH2-binding sites.
In IRS2, the kinase regulatory loop binding domain has been identified while IRS-4 has PTB and PH domains, which binds to INSR.
So far the binding domain has been crystalized from C2II and PA but not from CDTb, Ib or CSTb.
Various Rab11 family of interacting proteins (Rab11-FIPs), which contain a highly conserved C-terminal Rab binding domain have been identified [39]-[40] [39]-[40]
Mutually exclusive binding of Ca2+-CaM and other proteins to a common binding domain have been shown to play a role in the regulation of NMDA (N-methyl-D-aspartic acid) receptors, TRP (Transient Receptor Potential) channels and metabotropic glutamate receptors.
To date, all of the proteins containing a canonical AP2 DNA binding domain have been identified in land plants, but more divergent AP2 homologues have been hypothesized for cyanobacteria, ciliates and viruses [ 3, 6].
Accordingly, the relationship between the coiled-coil and CaM binding domains has been examined recently in Kv7.2 channels, suggesting that the stability of the helix D coiled-coil affects CaM binding and that it results in altered PIP2 sensitivity32.
In addition, there are numerous examples of domain amplification in the vertebrate lineage, including well-studied examples such as nebulin in which a super repeat of 7 actin binding domains has been amplified multiple times in many different vertebrate lineages (Bjorklund et al. 2010).
