Sentence examples for binding domain engineered by from inspiring English sources

To this end, we recently described E4rGel, a 40 KDa (estimated hydrodynamic diameter of ∼4 5 nm) immunotoxin comprised of a fusion of gelonin and a fibronectin type III binding domain engineered by directed evolution to exhibit 13 nM affinity for the EGFR.

Based on the same principle, artificial transcription factors (ATFs) have been generated by fusing various functional domains to a DNA binding domain engineered to bind to the genes of interest, thereby modulating their expression.

Filamentous phages displaying Lhr specific or Fshr specific decapeptides from the extracellular hormone binding domain were engineered.

We engineered MGAH22, a chimeric anti-HER2 monoclonal antibody with specificity and affinity similar to trastuzumab, with an Fc domain engineered for increased binding to both alleles of human CD16A.

This modularity allows for replacement of the native DNA-binding domain with engineered zinc finger proteins.

Surface display of metal-binding peptides, or protein domains into which metal binding properties has been engineered by combinatorial protein engineering, have been exploited to create staphylococcal bioadsorbents for potential environmental or biosensor applications.

By deleting the prephenate dehydrase domain, a functional chorismate mutase linked directly to the phenylalanine binding domain has been engineered and overexpressed.

This effort involved the construction and screening of 3 distinct libraries: a domain library that included several engineered binding domains isolated by phage-display; a lower-resolution linker library; and a higher-resolution linker library.

The extracellular domain (ECD) of Eph contains a highly conserved ligand binding domain (LBD), followed by a cysteine rich domain (CRD) and two fibronectin-type III domains (FN I & II).

Here, Tyrosines (Y), with phenyl group in the WT's binding domain, are replaced by Tryptophans (W) containing indole moiety.

The thermal stability of AR is only altered when the ligand binding domain is occupied by an agonist.