Sentence examples for binding domain encoded by from inspiring English sources

Mutations were most prominent in the DNA binding domain, encoded by exons 5 8, and only about five percent of the mutations were observed in exon 4 and exon 11.

Mamu-B*017:03 differs from Mamu-B*017:01 by four amino acids, three of which occur in the peptide binding domain encoded by exons 2-3.

In the case of TCF7L2, the alternative promoters produce protein isoforms that can activate or repress the WNT pathway dependent on the presence of β-catenin binding domain encoded by exons 1 and 2 (51).

Work form this laboratory previously identified a 21 amino acid paxillin binding domain encoded by exon 2 that is essential for the plasma membrane localization of merlin (Fernandez-Valle et al., 2002).

The additional ubiquitination sites of 0N4R and 2N4R tau in comparison to 2N3R tau allows us to assume, that these ubiquitination sites are localized in the second microtubule binding domain encoded by exon 10, which contains 5 lysine residues.

The MR gene contains an amino-terminal region that harbors a ligand-independent transactivation function coded by exon 2 and a conserved DNA binding domain encoded by exon 3-4 and a ligand binding domain responsible for ligand binding and ligand-dependent transactivation encoded by exons 5-9 [ 6].

Haematological tissue expresses three additional MXI1 isoforms, lacking either the SID-encoding first exon, the DNA-binding domain encoded by exon 3 or both these domains, which could also be considered in the oesophagus.

We and others have previously shown that the RBD (RNA-binding domain) encoded by exons 5 and 6 is sufficient for RNA binding [ 34, 39, 40].

However, patients treated with vemurafenib develop resistance by activation of alternative signaling pathways [ 6– 9] or by inducing alternative splicing of BRAF to exclude the RAS-binding domain encoded by exons 3 5 [ 10].

They occur frequently either in the kinase ATP-binding domain (encoded by exons 13 and 14) or in the activation loop (a-loop, encoded by exon 17), and typically affect the key amino acids that interact with imatinib binding to the kinase.

Not surprisingly, de Lima et al. also reported more missense mutations in the DNA-binding and protein-binding domains, encoded by exons 3 4 and 7 9, respectively.