Sentence examples for binding domain due to from inspiring English sources

CRLI route-dependent effects for acute inflammation are related to its carbohydrate binding domain (due to inhibition caused by the presence of α-methyl-mannoside), and are based on comparative analysis with ConA crystal structure.

A crucial aspect of oestrogen-ER interaction is the complete envelopment of the steroid in a hydrophobic pocket within the ligand binding domain due to the critical positioning of a 'lid' formed by helix 12 of the ER.

The flavin-free azoreductases might have lost the flavin-binding domain due to the mutation.

Third, it has been suggested that HLA-A68-restricted TCR might bind cognate antigen with higher affinity than those restricted by MHCI molecules with a canonical CD8-binding domain due to their thymic selection in the presence of a reduced pMHCI/CD8 interaction 17.

Overlaying our structure with the mouse MCAK structure reveals that the conformation of the neck linker region in the mouse MCAK/Kif2c structure does not allow binding of the CT domain, due to steric hindrance.

This effect is attributed to autoinhibition of sequence-specific DNA binding by the C-terminal domain due to increased DNA sliding [20], [21].

Thus, the reduced binding of polyubiquitinated proteins to the cue domain in httN138Q-containing lysates may be resulted from the increased binding of httN to the cue domain due to polyglutamine expansion.

As in the wildtype transporter, this asymmetry originates in the porter domain due to drug binding (Supplementary file 3A, Supplementary file 3B), compounded by the steric coupling between protomers in this region.

To cover the different mechanisms of Gigaxonin instability predicted by the 3D modelization, we selected patient's mutations affecting the homodimerization domain (R15S), the BTB folding and Cul3 binding (R138H), the folding of the KELCH domain due to single missense mutation (L309R) or massive truncation (R477X).

Typically, disintegrin cysteines form intramolecular bonds that rigidify the binding domain; furthermore, due to their high linear density, it is plausible these disulfides are less susceptible to standard reduction using β-mercaptoethanol.

A highly conserved DNA binding domain, termed 'forkhead' due to the physical appearance of Drosophila fork head mutants, defines forkhead gene family members.