Sentence examples for binding domain does not from inspiring English sources
(B ) Deletion of the importin-α binding domain does not affect the down-regulation of Per1 promoter activity by KPNB1.
(C ) Deletion of the importin-α binding domain does not affect the down-regulation of CLOCK-BMAL1-mediated Per1 transcription by KPNB1.
However, it seems unlikely that the 37W variant augments mitochondrial Kinesin-1 expression simply by increasing DISC1/Kinesin-1 interaction, because the known KIF5A binding domain does not include the region of DISC1 encompassing R37 (30).
The protein phosphatase 2A (PP2A) binding domain of MCV sT interacts with PP2A, as also seen with SV40 sT, but mutation of the PP2A binding domain does not impair the oncogenicity of MCV sT.
Our results indicate that the HMG interaction is weak and not sufficient for Groucho/TLE repression in vivo, because a deletion mutation that removes the CRD but retains the HMG DNA binding domain does not support Groucho-mediated repression (data not shown).
Pull down assays with purified proteins recapitulated our previous results: His6-tagged full-length BiP and BiP ATPase domain proteins were able to form an interaction with luminal domain of Ire1 and Perk, while His6-tagged BiP substrate binding domain did not bind to Ire1 and Perk luminal domains.
Deletion of the DNA binding domain did not affect nuclear import nor association with chromosomes, but resulted in pronounced large continuous (or aggregated) structures.
Fis-wt and Fis-R71C (cysteine near DNA binding domain) do not generate Hin crosslinks (Dhar et al., 2009a).
As the residues in the binding domain do not lie in the disordered region, the binding domain of PXR protein has a stable structure in protein folding.
As the residues in the binding domain do not lie in the disordered region, the binding domain of Smo protein has a stable structure in protein folding.
Nevertheless, as shown here, the expressed GFP-ATM1 which is a mutant molecule lacking the head, actin binding domain, did not disrupt the ER network.
