The homeodomain is a ~60 amino acid DNA binding domain composed of a helix-turn-helix structure that folds into three characteristic alpha-helices, capable of interacting specifically with DNA [ 2].
They all consist of a highly similar N-terminal membrane binding domain composed of 24 ankyrin (ANK) repeats, a spectrin-binding domain comprised of two ZU5 domains, and a UPA domain followed by a death domain (DD) and a variable C-terminal regulatory domain (Bennett and Lorenzo, 2013).
The β-catenin-binding domain has been mapped to amino acid residues 535 636 of mXinα, which overlaps with the known actin binding domains composed of Xin repeats (XR17∼XR19) [1], [5], [7], [9].
Hsd11b proteins possess a superfamily Rossmann-fold NAD(P H/NAD(P) binding domains composed of a glucose/ribitol dehydrogenase domain and a short chain dehydrogenase domain.
Ralstonia solanacearum TALE-like proteins (RTLs) exhibit similar structural features to TALEs, including a central DNA-binding domain composed of 35 amino acid-long repeats.
This gene consists of 21 exons with a combined length of 2 928 bp, and is made up of a cysteine-rich extracellular ligand-binding domain composed of five immunoglobulin-like domains, a transmembrane domain, and an intracellular domain with two separate tyrosine kinase domains [ 23, 29].
The Csf1ra protein functions as membrane spanning cell surface receptor [ 29, 32], and is characterized by a cysteine-rich extracellular ligand-binding domain composed of five immunoglobulin-like domains containing growth factor binding sites, a transmembrane domain, and two separate tyrosine kinase domains [ 23, 29].
TALEs are naturally occurring proteins from plant pathogenic bacteria, which contain DNA-binding domains composed of a series of 34 amino acid repeat domains that each recognize a single bp of DNA through two hypervariable residues.
These enzymes are engineered to contain a zinc finger DNA-binding domain (composed, typically, of 3 6 zinc fingers) and the nonsequence-specific DNA-cleavage domain from the FokI type II restriction endonuclease (Fn domain) [ 115].
Both proteins form 50 nm long intramolecular coiled coils with a central hinge/dimerization domain at one end and an ABC (ATP- binding cassette -like ATPase head domain cassette -like ATPaseterminal domains at theadther.
In CBM5 of SgChiC, two Trp residues are conserved and function in carbohydrate binding on the surface of the domain composed of a triple antiparallel β-sheet (Akagi et al. 2006; Itoh et al. 2006; Kezuka et al. 2006).
