Sentence examples for binding domain close to from inspiring English sources

A binding domain close to the extracellular mouth was also characterized for serotonin selective reuptake inhibitors at neuronal AChRs, as well as for SADU-3-72 (a bupropion photoactivatable analogue) and other NCAs at muscle AChRs.

ER and PR are members of the nuclear hormone receptor (HR) superfamily; they contain structurally conserved and functionally distinct domains that include a central DNA binding domain, a ligand binding domain close to the COOH terminus, variable NH2-terminal domains related to transcriptional activation/repression and the well-characterized transcriptional activation domains AF-1 and AF-2 [ 4].

H. pylori Fur's distinctive N-terminal arm was identified as part of a well-defined structure in the recently released zinc-loaded Fur protein structure [9], with residue R3 participating in a hydrogen bond network with residues in the DNA-binding domain close to metal-binding residue H42 (Fig. 2).

Comparative analysis of the low-energy ligand conformations found the preferred site for Ssa and Ssd to be within the transmembrane domain, close to the thapsigargin-binding site.

The cleavage site is situated between the third and the fourth extracellular domain close to a calcium-binding site [ 6] as indicated in figure 1.

Given that Hsp40 stimulates the ATPase activity of Hsp70, and the observation of the J domain close to the nucleotide-binding site in Hsp70 (residues 24 246), we also considered Hsp70 in the undocked ADP form.

Of note, three out of five RTKs (NTRK2, IGF1R and EGFR) were affected by mutations in the tyrosine kinase domain in at least one of the samples investigated, and the remaining mutations mostly affected the furin-like domains or the region between two furin-like domains, close to the ligand-binding domain.

In A/H5N1 strains isolated in Egypt, several substitutions were found in the receptor binding domain, or close proximity to it (table 3).

The PPIase activity of P2 has been shown to be increased in the presence of the adjacent chaperone domain, presumably as this domain facilitates substrate binding close to the active site of P2 [82].

The inserted Cu+ binding domain is positioned close enough to the fluorophore of EYFP to cause a change in the local environment and detectably alter its fluorescent properties when Cu+ binds.

The putative calmodulin-binding domain is very close to the amino terminus of the protein.