Sentence examples for binding domain can be from inspiring English sources

These mutations of the p53 DNA binding domain can be divided into two groups [ 24].

However acetylation of p53 at K120 within the DNA binding domain can be catalysed by TIP60 in response to DNA damage, and has been implicated in activation of pro-apoptotic pathways both dependent on and independent of transcription [ 25- 27].

The targets of the DNA binding domain can be identified using a technique called ChIP-seq, in which chromatin immunoprecipitation (ChIP) of a transcription factor is coupled to sequencing (-seq) of its target DNA.

Since we are using a nucleosomal template containing both LexA and Gal4 binding sites, chimeric proteins containing a LexA or Gal4 DNA binding domain can be used and fused to distinct peptides or protein domains that are known to interact with a particular chromatin modifying enzyme.

The coupled CRIB and PDZ architecture of Par-6 reveals how simple binding domains can be combined to yield complex regulation.

This procedure results in a library containing phages displaying polypeptides of varying sizes and thus, from such a library, also proteins containing large binding domains can be isolated.

To further investigate the consequence(s) of acetylation on tau, we evaluated the amino acid residues reported to be acetylated by p300, and found all four KXGS motifs in tau's microtubule-binding domain can be modified by acetylation (22).

The DNA-binding domain can be customised to recognise virtually any sequence using a modular recognition code that is bound by TALE proteins, a group of naturally occurring proteins found in plant bacteria (Boch et al., 2009).

The binding affinity of the steroid receptor coactivator SRC3 to complexes of ligands with the ERα ligand-binding domain can be quantified by a time-resolved fluorescence resonance transfer assay (tr-FRET) (Jeyakumar et al, 2011).

Using genetic engineering a single NAR variable (V) antigen-binding domain can be expressed as a separate soluble protein often referred to as a shark single domain antibody (sdAb).

Zinc finger DNA-binding domains can be combined to create new proteins of desired DNA-binding specificity.