Each enantiomer, in the protonated and neutral state, interacts with binding domains by a combination of van der Waals, hydrogen bond, and electrostatic contacts.
Berrodin and colleagues [ 97] evaluated the effects of BZA, RLX, and LAS on CE-mediated recruitment of 43 cofactor peptides to the ERα-ligand-binding domain by a multiplex biochemical assay.
The majority of glucoamylases are multidomain enzymes consisting of a catalytic domain connected to a starch-binding domain by an O-glycosylated linker region.
We report on the finding that the LIM domain proteins TRIP6 can interact with the POT1 DNA binding domain by two-hybrid, an interaction that we confirmed in human cells.
To decipher the different roles of Rfx6, we generated a conditional knockout mouse by flanking exon 3, which encodes a part of the DNA binding domain, by two loxP sites, generating a null allele.
Harbinson et al.[ 25] identified a Thi2p binding domain by genome-wide chromatin immuno-precipitation and we observed this sequence in the promoter region of both TNP1 and AAD14.
OPG is a glycoprotein possessing 4 cysteine-rich domains at its Nterminus by which it binds to RANKL, whereas its C-terminus contains 22 homologous death domains of unknown function and a heparin binding domain by which the glycoprotein interacts with matrix macromolecules, such as glycosaminoglycans and proteoglycans.
The first mutation, Ala353Val, is in the so-called pseudouridine and archaeosine transglycosylase (PUA) domain, which has been proposed as an RNA binding domain, by analogy with the archael and Escherichia coli homologues, Cbf5 and TruB, respectively.
Protein 4.1 95) mRNA encodes a protein with two spectrin-actin binding domains by virtue of a 369 nt duplication of codons for Lys407-Gln529.
