Your English writing platform
Discover LudwigSuggestions(4)
Exact(10)
EPM2A encodes laforin, a dual specificity phosphatase of 331 amino acids with a functional carbohydrate binding domain at the N-terminus ([7], [8]).
The toxins are single chain proteins of an A/B type structure where the catalytic active glucosyltransferase domain is located at the N-terminus and the proposed receptor binding domain at the C-terminus [2].
To investigate conservation of the binding domain at the atomic level we compared the PDZ3 CRIPT interaction in Rattus norvegius (rat), Danio renio (fish), Drosophila melanogaster (fly), Anopheles gambiae (mosquito), Strongylocentrotus purpuratus (sea urchin), Caenorhabditis elegans (worm), Nematostella vectensis (cnidarian), and Amphimedon queenslandica (sponge) (Figure S3).
These isoforms differ by the presence or absence of two N-terminal inserts (exon 2 and/or 3 inclusion) and the presence of either three or four imperfect repeats (3R or 4R) in the microtubule binding domain at the C-terminus (exon 10 inclusion) [2], [6] [8].
Compared to other xylanases from the same genus, it has one more carbohydrate binding domain at the C-terminal of the protein through a BLAST search.
Two proteins each for IleRS (orf19.2138 and orf19.2382) and LeuRS (orf19.2560 and 5705) were predicted to have anti-codon binding domain at the C-terminal of catalytic domain.
Similar(50)
HMMER3 identified 918 pstB homologs in the 1000 bp dataset, of which 853 (∼93%) matched the top three conserved domains: PF00005 (an ABC-transporter conserved domain), PF02463 (a superfamily with ATP binding domains at the N and C termini) and PF03193 (a family of unknown function that is a member of P-loop containing NTP hydrolases) in a reciprocal hmmsearch using the PFAM-A HMM as a query.
In Chd1, these accessory domains include tandem chromodomains at the N-terminus and DNA binding domains at the C-terminus that flank the central helicase.
All the genes were found to have the ferric reductase domain toward the middle of the coding sequence followed by FAD and NAD binding domains at the 3' end of the gene.
Domain architecture analysis of the deduced zHSF2 sequence revealed the presence of a DNA-binding domain at the N-terminal end, an adjacent oligomerization domain and a vertebrate heat shock transcription factor domain.
Analysis of the SimReg1 amino acid sequence using ExPASy Proteomics Server http://expasy.org revealed a putative signal receiver domain (the REC domain, aa 15-123) located athehe N-terminal part of the protein and a DNA-binding domain at the C-terminus (aa 167-239).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com