Sentence examples for binding domain as it from inspiring English sources
To dissect the molecular basis of the interaction between Ire1 and Perk with BiP, we tested if this interaction was mediated by the canonical substrate binding domain, as it is the case for this chaperone, or the ATPase domain.
The effects of the energy barriers for detaching the masking domain and the ligand from the binding domain, as well as the effects of the properties of the polypeptide chain connecting the contiguous domains, are also studied.
The 16 amino acids lacking in the sequence of sAPPβ have been shown to be a heparin binding domain as well [13].
The deduced amino acid sequence reveals the conserved carbohydrate binding domain as well as the Ca2+ interaction amino acid residues.
The antennae region projects out from the top of each NAD+ binding domain, as well as intersecting near the GTP allosteric site.
All known animal TPX2 proteins have an Aurora binding domain as well as RNA binding and recognition domains, and thus probably fulfil the same function in the different species (Weiner and Bornberg-Bauer 2006).
We show here that subfunctionalization of the individual members occurred through the modification of structural properties (KRAB protein interaction domain; ZNF DNA binding domain) as well as through fine-tuned tissue expression patterns.
Mutations in a binding domain, as well as in regulatory regions [ 48, 49], for example in a transcription factor, could negatively effect the expression of genes and therefore such mutations might be selected against.
Mutations between codons 867 and 1114, which affect the I β-catenin binding domain, as well as mutations occurring in exons 6 and 9, predicted to result in null alleles, were associated with a less severe colorectal pathophenotype.
As control, we used a trans-splicing molecule with no binding domain (AS-).
The two enzymes harbor double-stranded RNA binding domains as well as a catalytic deaminase domain that is evolutionary related to tRNA specific adenosine deaminases, and more distantly to cytidine deaminases.
