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Group I BPL (Mycobacterium tuberculosis BPL – 266 amino acids) lacks N-terminal DNA binding domain and hence probably does not function as a repressor (13).
The modified motifs encompass the internal and the C-terminal (loss of the MTTV sequence) Dvl binding domain, and hence, Dact4 proteins may be unable to regulate this key molecule essential for all Wnt pathways.
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Interestingly, its DNA-binding domain (and hence its hotspot motif selectivity) is evolving rapidly, and there is apparently positive selection for newly arising variants, at least in some taxa (Oliver et al. 2009; Thomas et al. 2009; Ponting 2011).
As proposed for p97, it is conceivable that in general the state of the bound nucleotide is transmitted to induce a relative movement between D1 and D2, which displaces the N-terminal substrate-binding domain and hence exerts the pulling force required for substrate extraction [20,36].
STING lacks a high-affinity DNA binding domain 50 and hence may not be a direct DNA sensor.
The AhR protein contains a bHLH DNA binding domain and a Per-Arnt-Sim (PAS) domain for agonist binding.
Furthermore, cytoplasmic domains like the cyclic nucleotide binding domain and the PAS domain have been positioned in the overall structure.
The enzyme consists of two domains, an NADH binding domain and a so-called octopine-binding domain.
PF00258 = flavodoxin domain, PF00667 = FAD binding domain and PF00175 = NAD-binding domain.
Hsp70 consists of a nucleotide binding domain (NBD), substrate binding domain, and a C-terminal domain.
The overall enzyme structure comprises two domains, the FAD binding domain and the substrate binding domain.
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