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MECP2 encodes a nuclear protein containing methyl CpG binding domain and can specifically bind to methylated DNA [ 19].
PLU-1/Jarid1B contains a DNA binding domain, and can be recruited to DNA through binding to transcription factors.
The problem with VASP as a 'side-binder' is that it contains a g-actin binding domain and can function as a polymerase.
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Due to combinatorial reasons the number of distinguishable species grows exponentially with the number of binding domains and can easily reach several millions.
Sp1 is part of a family of transcription factors (Sp1 Sp4) which share highly conserved DNA binding domains and can function co-operatively to regulate transcription of a multitude of genes [ 28].
Most transcription factors reported are predicted based on their DNA-binding domain and can be subdivided based on a variety of characteristics such as the number of repeats [ 62].
This interaction may explain how pro- and ppIL-1α can transactivate gene expression of a Gal-4 reporter when fused to the Gal-4 DNA-binding domain, and can directly activate NFκB- and activator protein-1-dependent transcription (Buryskova et al., 2004; Werman et al., 2004).
Fv2-Fu contains two FK506-binding domains and can be induced to form a dimer or oligomer upon AP20187 treatment.
These RBPs usually contain several RNA-binding domains and can associate with more than one mRNA; this multi-valency further favors the coalescence of RNA-protein granules.
Whether the Grb2 binding domain and the PI3K domain can be engaged simultaneously or occurs sequentially is yet to be determined.
The core DNA binding domain and the canonical p53 RE can therefore be designated as an evolutionary conserved module.
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