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Finally, binding does not always suggest function.
Moreover, GM1 binding does not always correlate with intoxication.
It is also assumed that SLCO2A1 contains several different substrate binding sites, to which binding does not always result in substrate translocation across the membrane [ 15].
The binding of T7 RNAP to promoter DNA is very fast, limited only by diffusion, but this binding does not always result in transcription because the RNAP can also dissociate from the DNA.
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Overall, we found that although the effects of metal mixture interactions on gill metal binding did not always match with our original assumptions, the effects of metal mixtures on toxicity in fish were generally consistent with our predictions.
We also found that STAT6 binding did not always result in transcriptional activation.
Although we have shown that NSAIDs block the DNA-binding step in NF-κB activation, DNA binding alone does not always correlate with NF-κB-dependent gene transcription, suggesting that there are additional regulatory steps (Nasuhara et al., 1999).
Taken together with the inability of RIG-I to signal on the dumbbell, we conclude that ATP binding and hydrolysis does not always lead to signaling.
MOTIVATION: The DNA binding specificity of a transcription factor (TF) is typically represented using a position weight matrix model, which implicitly assumes that individual bases in a TF binding site contribute independently to the binding affinity, an assumption that does not always hold.
Motivation: The DNA binding specificity of a transcription factor (TF) is typically represented using a position weight matrix model, which implicitly assumes that individual bases in a TF binding site contribute independently to the binding affinity, an assumption that does not always hold.
Thus, we can conclude that the binding affinity to target proteins does not always concur with the chaperone activity data.
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