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The latter finding is in apparent contradiction with mutational studies indicating that crucial diltiazem binding determinants overlap with determinants of PAA sensitivity located deeply in the channel pore (Hering et al., 1996; Kraus et al., 1998; Berjukow et al., 1999; Hockerman et al., 2000; Dilmac et al., 2003).
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Second, their in-vivo binding profiles will overlap with p63 binding profile.
Moreover, several significant TF binding peaks overlap with these enhancers.
At each of these promoters, the observed transcription factor binding peaks overlap with Hog1 promoter peaks.
For the other E-box-binding proteins, USF1 binding signal overlapped with the E-boxes 1 8 (Supplementary Figure S1).
In myocytes, 40% of MLL4 binding regions overlapped with those of MyoD.
Furthermore, majority of FoxA2 binding events overlapped with the hypersensitive nucleosomes at active enhancers.
In contrast, only 43% of RARα binding sites overlapped with those of RXRα.
Again the highest scoring binding pocket (R=50) overlapped with the heme binding site.
The pertuzumab-binding site does not overlap with the trastuzumab epitope on HER2 [ 70, 71].
CtrA's binding sites are overlapping with a DnaA box and the IHF binding site.
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