Sentence examples for binding determinants of the from inspiring English sources

To understand the binding determinants of the different analogs, hydrogen bonding and van der Waals contributions, and water molecule bridging in the EGFR analog complexes were analyzed.

The structures reveal a nucleotide binding domain comprising a five-blade β propeller, binding determinants of the substrate and the active site, and an unusual calcium binding site with a potential regulatory function.

Actually, the strongest binding determinants of the α4-helix are: its global accessibility at the CCD surface, and, especially, the large exposition to solvent of the polar/charged side chains of residues as for instance Gln148, Lys156 and Lys159 (Fig. 1-A).

Further delineation of the binding determinants of the NCOA4-FTH1 complex will require structural approaches.

The VDAC-based peptides used in the current study were originally designed based on the binding determinants of the VDAC1/Bcl-2 interandion, and later identified as being effective at disrupting VDAC/Bcl-xL.

This combined approach led to useful insights into the binding determinants of thaperoxides to the malarial enzyme.

A battery of 3AB variants (eight clustered-charge-to-alanine changes and five single-amino-acid mutations) has been used to map the binding determinants of 3AB-3AB interaction which were found to differ from the amino acids critical for the 3AB-3Dpol interaction.

Our study provides insights into the mechanisms of DNA recognition by bHLH dimers as well as a blueprint for system-level studies of the DNA binding determinants of other TF families in different model organisms and humans.

We first investigated whether the MHC class II binding determinants of HCV F protein could specifically stimulate CD4+ T cell response by DNA vaccination in humanized mouse models.

Critics of corporate governance solutions dismiss them as non-binding and therefore meaningless, whereas Ruggie and others maintain that business embrace of the UNGPs changes the "social norms and expectations" in the corporate governance space, and that, once cemented, the norms are just as binding determinants of behavior as any law, if not more so.

Moreover, the main tRNA binding determinant of Ec ProRS is the anticodon interaction, and therefore any contribution of K279 to binding/positioning of the 5′-CCA-Ala end of the tRNA is difficult to measure and quantify.