Sentence examples for binding defect than the from inspiring English sources

We attempted to test this hypothesis by making numerous combinatorial mutations, (including a V447H K484A D517A triple mutant), none of which exhibited a substantially greater UBL binding defect than the D517A or K484A alleles (Additional file 3, Table S1).

None of these mutants, which are listed in Additional file 3, Table S1, exhibited a greater UBL binding defect than the D517A or K484A alleles and so they were not pursued further.

Thus, at least part of the binding defect associated with the R1699W mutation is likely due to protein destabilization.

Since the K45A mutant still demethylates despite inactivated specific RNA binding, the RNA binding defect of G39A may not be the cause for the demethylation defect.

The dissociation rates for all Y766A complexes were higher than for the other proteins, reflecting the DNA binding defect associated with Y766A.

Rather than a 14-3-3 14-3-3 14-3-3t, we show that cell cycle arrest mutants are impaired for the abindingto recruit G2,M regulatory proteins to 14-3-3.

Of the three mutations, Smc1 F584R has the most drastic binding defect.

This behavior is consistent with a DNA binding defect in pol β(L22P) rather than a nucleotide insertion deficiency.

The intent seems to be to demonstrate more clearly than in Figure 2E a binding defects for Rev-Q51A.

However, BmrR exhibits only drug-specific binding defects, whereby R6G binding affinity drops nearly 100-fold in the E253Q substituted protein but Be affinity does not change [12].

Intriguingly, however, the mutants of S365A, S365E, V372A, V372D, D380A and E383A showed more defects than the p62 PH-D-binding defective mutants.