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In contrast, as mentioned above, in cells expressing A2AR-D2R, curvesition curves were biphasic, and binding data were then fitted to eq. 2 (Methods) and robust parameters were obtained (Table 4).
The binding data were then analysed to produce a position weight matrix (PWM) of the TF-binding site.
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Genome-wide binding data was then employed to identify direct binding targets of each transcription factor.
The DNA-binding data were then used to identify putative binding sites within the human genome to assess the impact of the differences in DNA-binding specificity.
Therefore, these three ChIP seq data were then downloaded and analyzed to explore the binding site targets of individual factors.
These sequence data were then analyzed for significant enrichment of transcription factor binding site sequences.
These data were then correlated with region-matched Aβ plaque load and peptide levels, [H]PiB binding in vitro, and in vivo PET retention levels.
Data were then log transformed.
Data were then statistically analyzed.
Data were then analyzed thematically.
These data were then discarded.
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