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In vitro receptor subtype (μ, κ, and δ opioid receptors) binding data of the carbamate and sulfonate derivatives is reported.
Cannabinoid receptor binding data of the series allowed identifying steric constraints within the CB2 binding pocket using a study of Van der Waals' volume maps.
Using the binding data of the Ambit study of 72 inhibitors and their interactions with 442 kinases [40], correlation analysis highlights the similarity of ALK and MET, and the dissimilarity of EGFR (Fig. 3).
The dose-dependant glycan binding data of the described HAs were used to calculate Kd' and n values (n ∼1.3 for all the HAs) by fitting the binding data to the Hill equation (for multivalent binding) and this was then used to generate theoretical binding curves to clearly distinguish the relative binding affinities of WT and mutant H2 HAs to representative avian and human receptors (Figure 6).
The lectin-sperm binding data of the lectins which showed positive binding (S/B ≥ 2) to at least one sperm sample were used as input for clustering.
To learn transcriptional regulatory models, we constructed a training data set for each time point using the TF binding data of the positive and negative genes as described above.
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The binding data of this molecule is much better reproduced by the spreading model, which hypothesizes different binding orientations, than by the well-known Langmuir model.
Based on [3H]-binding data of the glitazones and comparisons to computer generated Kis, we were able to predict that site 1 was likely the target of the glitazones.
The results of this study imply that the TF binding data of Hap4 is the more relevant one.
When analyzing the genome-wide binding data of some TF (hereafter called the primary factor), the goal is to learn the TFs (called cooperative factors) that interact with this factor, as well as the relevant model parameters.
Our pervious work has shown that incorporating binding data of MHC-I molecules in the same supertype can alleviate the scarcity of binding data and improve the prediction accuracy [ 24].
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