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We evaluated each of the motifs on independent data sets (e.g., asking whether a motif derived from in vivo binding data is consistent with in vitro binding data or with the effects of TF perturbation on gene expression) and manually examined the results, as well as the literature on the protein of interest.
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DOI: http://dx.doi.org/10.7554/eLife.09391.012 While the equilibrium binding data are consistent with a nucleotide-stimulated dissociation mechanism, we next wanted to directly measure RIG-I dissociation from RNA to determine whether the dissociation rate constant is altered by nucleotide binding.
In vitro binding data are consistent with the hypothetical model shown in Figure 6c in which Jnk1 and p38 α interact with different regions (referred to as D2 and D3) in the central part as well as with the C-terminal part of B-Myb.
Since eIF3 cooperates with the cap-binding eIF4 complex in directing the 5' end of mRNAs to the 40S ribosome, and several eIF3 subunits contain RNA binding motifs, our data is consistent with a model in which eIF3 complexes defined by distinct PCI proteins recognize determining features of mRNAs presented to the 40S subunit in concert with eIF4.
Because of the sensitivity of chemical shift perturbations to allosteric structural changes, the authors should consider modifying the statement "Strong perturbations indicate that PK9119 … binds" to indicate that the perturbation data is consistent with PK9119 binding to the hydrophobic pocket.
This data is consistent with Gulf veteran mortality.
Our data is consistent with these facts.
"The data is consistent with GDP falling about 0.5percentt".
Moreover, our gene expression, transcription factor binding and computational data are consistent with the existence of the GR-KLF9-KLF2 incoherent FFL.
Some countries have labor laws that allow light work before the minimum age of employment, and there is one country, Trinidad and Tobago, where the data are consistent with binding light work regulations.
These data are consistent with binding profiles in ES cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com