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However, based on the DNA binding data for both condensin and the condensin-like bacterial mukB complexes which demonstrate tight DNA-SMC head interactions, as well as imaging of the condensin complex to DNA which reveals the association of the head domain to DNA, it is possible that the Smc1 and Smc3 heads bind to chromatin [20], [32], [33].
Extracted binding data for both midazolam and ketoconazole were fit to Eqs. 4 7 utilizing the statistics software R version 2.12 (ref. 30) and the nonlinear least squares function to determine the binding parameters for either an BI or BC model.
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Relevant to our study, we were able to download binding data for AP1 (both FOS and JUN), ATF3, MYC, NFKB1, and STAT1 TFs.
The competitive binding data for each ligand was tested for both one and two -site binding.
To identify these genes we developed a metric that accounts for both the significance of the expression change and binding data for each gene (described in detail in Methods).
Furthermore human serum albumin has been the preferred albumin and interpretation of binding data for human serum albumin in terms of BSA structure should proceed with caution as both albumins only share 76% sequence homology.
a, SPR binding data for the interaction of WM-8014 wimmobilizedized KAT6A and KAT7 MYST domains.
Training data consisted of sequences and binding data for nonamer (nine amino acid) peptides.
Independent test data consisted of sequences and binding data for peptides of length ≤25.
a, SPR binding data for the interaction of WM-1119 wimmobilizedized KAT6A, KAT7 and KAT5, compared with the interaction of WM-8014.
Intriguingly, while both BLI and SwitchSENSE demonstrated efficient target recognition for Cas9 tracrRNA crRNA complexes and no recognition for crDNA equivalents, the binding data for crHyb varied between the two methods.
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