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Integrating new dynamic binding data for additional TFs should allow expansion of the GATA1-GATA2-PU.1 kernel to generate more extensive regulatory modules.
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Additional table showing PDSP off-target binding data for 4hh.
a, SPR binding data for the interaction of WM-8014 wimmobilizedized KAT6A and KAT7 MYST domains.
The competitive binding data for each ligand was tested for both one and two -site binding.
See Supplementary Data for additional details.
Please see Supplementary data for additional information.
This additional degree of freedom, which cannot be directly ascertained from experimental peptide binding data, makes epitope prediction for class II MHC more difficult than for class I MHC.
Next, a methyl scan of the ring was performed to investigate the binding site for additional space (11 13).
We varied " " of the DNA duplex stability data (for both double and single strand binding data), which is supposed to have more effect on the results (recall that " " weights different information sources and reflects their importance), and listed its AUC scores for single data source as well as its combination with other additional information sources in supplementary Table.
The linear weighting approach means that different or additional properties can also be included as suits a particular project, such as competition assessments, NMR binding data, thermal melt or enzyme inhibition data, etc. Points were assigned for each property (2 points for a high bin, 1 for a medium, and zero for a low bin).
AUROC scores for in vivo and in vitro defined motifs on in vivo binding data.
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