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With the advent of genome-scale maps of protein-protein interactions and transcription factor-DNA binding data, available from different groups and through databases, such as TRANSPATH (http://www.biobase.de), BioCarta (www.biocarta.com), and STKE (www.stke.org), discrete dynamic models can capitalize upon these resources to derive the network architecture.
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These predictions were validated against the mutagenesis data available from the RILM online database [69], and were found to be in agreement with previous insulin binding models.
The data available from the ONS runs from 1977 to 2011.
Data available from 135 patients.
†No data available from Australia.
There is also data available from grandparents.
HWC data available from 1997 to 2001.
In contrast to CTCF, no genome-wide binding data are available for the thyroid hormone receptor.
Genome-wide binding data from blastoderm embryos is available from the Berkeley Drosophila Transcriptional Network Project [ 34] and data from later stages of embryogenesis was generated as part of the modENCODE project [ 35].
All small RNA, CTCF binding and RNAPII binding data were obtained from publicly available sources and are listed in detail in Additional file 1, Table S1.
To determine how many of the compensated genes are significantly bound by the MSL-complex we used available MOF binding data from male salivary glands [ 28].
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