Scatchard plots of the binding data indicate that [18F]-9 binds to a single high affinity site on AD homogenates and Aβ1 42 fibrils (Fig. 5C,D).
AUROC scores for in vivo and in vitro defined motifs on in vivo binding data.
The in vitro binding data confirmed our conformational hypothesis.
This chapter discusses the analysis of drug-DNA binding data.
a, SPR binding data for the interaction of WM-8014 wimmobilizedized KAT6A and KAT7 MYST domains.
Another regulatory network was generated by combining genome-wide transcription factor binding data, knockout expression data, and sequence conservation40.
DNA from the aliquot before immunoprecipitation was serially diluted and used to generate a standard curve for quantitative determination of DNA binding data calculated as % input.
At right, the fraction of the aptamer that is folded was calculated by quantifying Bmax using a Scatchard plot of the binding data.
The binding data were zero adjusted and the maximum binding responses of the individual injections were normalized using the BIAevaluation software version 4.1.
a, SPR binding data for the interaction of WM-1119 wimmobilizedized KAT6A, KAT7 and KAT5, compared with the interaction of WM-8014.
The method has been validated using literature plasma protein binding data of 68 known drug molecules.
