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Instead, one might speculate that dsRNA binding could be important to mediate the rapid export observed in the absence of C33 or of a functional CHCC motif.
Together with the liposome-binding assay, this suggests that Nup53 membrane binding could be important for NPC assembly and formation of a closed NE.
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Therefore, LMα1LG4-5 binding to dystroglycan could be important not only for basement membrane assembly in the muscle, but also for its maintenance.
However, other MAP proteins could be involved in FN binding and they could be important for host-pathogen interactions.
It could also prevent or reverse Rad51 binding to repair intermediates, which could be important for preventing the nascent strand from pairing to generate chicken-foot structures that occur at stalled replication forks [55].
While the difference in LigB-12 could be important for binding of a host protein, the position of the residues along the terminal surface are probably related to adaptive interactions with the nonrepeat terminal domain.
However, we do not know the binding affinity of each enantiomer, which could be important for explaining the distinct pharmacologic activity of (S -- and (R --mecamylamine on each α4β2 AChR --mecamylamine
Conformational changes involving the A−B loop could be important in controlling cooperative binding because of its proximity to important ligand binding sites.
Therefore, N-myristylation may keep the C-subunit in a relatively stable conformation, which could be important for ligand binding and activity.
Interestingly, in Jmjd6, like in Hif1an and Jmjd2a, a lysine (Lys204, from DSBH β-strand IV) could be important for the binding of the C5'-carboxylate of 2OG.
Finally, the structure of ATP-bound hTRPV4-ARD and comparisons to TRPV2 and TRPV6 suggest that a previously unrecognized residue, Phe231 in hTRPV4-ARD, could be important for ATP binding.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com