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RPA is detected transiently at telomeres at this time (Schramke et al. 2003; McGee et al. 2010), but this binding could be explained by the RPA that associates with telomeres during semiconservative replication (McGee et al. 2010).
Such permanent binding could be explained by the fact that Fe, especially together with Na, can lower the melting point of silica leading to vitrification of the particle surface.
Assuming two-state exchange is the basis of the allosteric effect, the difference in linkage between SLII and SLIV binding and U2A′ binding could be explained by substantially different affinities of the RNAs for the two states (in eq 6, βSLIV ≫ βSLII).
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Indeed, a recent analysis of yeast ChIP-Chip data revealed that only 48% of detected transcription factor binding sites could be explained by direct binding and an additional 16% by indirect binding [ 28].
The sheer number of chemical shift changes in the finger print region upon L-arginine binding indicates that much more residues are affected upon substrate binding as could be explained by a sole and physical interaction of the protein with the substrate.
Specifically we test whether the presence of the YY1 binding sites could be explained by DNA sequence or amino acid motif conservation.
The prevalence of 'neoplasms' annotations in the 'protein kinase binding' list could be explained by the importance of growth factor pathways in cancers, with protein kinases playing key roles in regulating growth factor pathways.
Related to Figure 2 The M2 motif identified within a subset of the CTCF binding events could be explained by (1) direct interaction of CTCF with M2 or (2) interaction of another molecule (protein or RNA) with M2, as suggested by Boyle et al.
In case of the mixture with gum arabic, a decrease is observed in the fluorescence attributed to the binding medium that could be explained by a quenching effect [41].
Thus, as Epe1 recruitment to heterochromatin depends on Swi6, spreading of H3K9 methylation in the absence of Swi6, or Swi6 binding to H3K9me2, could be explained by failure to recruit Epe1 (Zofall & Grewal, 2006).
The incompatibility of binding by SRSF1 with binding by DHX36 and nucleolin could be explained if the binding of the latter two proteins, unlike hnRNP F/H or CNBP, required the entire ESE domain.
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