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The detachment of the dual action ligand from the receptor is more likely to be followed by re-attachment if there are GRPR binding copies close to it, resulting in higher receptor affinity for homodimers and better tumor uptake with longer tumor retention [26].
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A closer inspection, however, reveals that 3 of them have exact copies close to each other.
Coupled with opening and closing of FABP4, the ligand may exist in two different binding modes: close to the bottom of the cavity or close to the portal.
These binding energies are close to the reported values of the binding state of Zn2+[19].
An increase in the expression of the single X gene copy in the male brings the expression level closer to that of the two female copies and close to that of autosomes.
Extended Data Fig. 1 METTL3 binding close to the stop codon enhances translation.
The issues that are less economically impactful, or are non-binding, are close to being resolved.
Quinalizarin interacts with the ATP-binding cleft by positioning close to the phosphate binding region.
Some of these copies may be close to each other on the genome while others are not.
Restriction Note: Originals and Reference Master copies are closed to patron use.
The original binding for an MH is kept in its HA, but ROMIP supports that a binding copy can be propagated to the requiring nodes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com