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A slight but insignificant decrease in binding cooperativity was also observed.
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That all mutant proteins exhibit a comparable modest negative cooperativity is also consistent with a common mode of binding.
Cooperativity is also observed at the level of DM-mediated peptide binding in the absence of a prebound peptide.
Like ∆G C1/2/3 terms, the energy terms associated with cooperativity is also in balance: W_{text{C1}} + W_{text{C2}} + W_{text{C3}} = 0.
However, we note that the loss of cooperativity is also observed in the transporter that is cross-linked in the inward facing state, suggesting that binding/dissociation in this isolated state is affected.
Since cofilin's binding cooperativity is mediated by the filament's twist, it can also be considered a structure-sensing mechanism.
That MftR binds urate with modest negative cooperativity is consistent with the existence of two sites; such negative cooperativity of urate binding was also observed for HucR and PecS.
Surprisingly, SLIV/U1A/U2A′ binding is also characterized by a large linkage and/or cooperativity parameter, but the protein protein interaction is much weaker (micromolar), effectively preventing the formation of this ternary complex in vivo.
From a strictly mathematical viewpoint, the enhanced sensitivity of quenching parameters over cooperativity parameters is also not surprising.
It was also shown that the Doc-mediated enhancement of Phd binding to operator that represents an illustration of the conditional cooperativity (or directional assembly) can be explained by the intrinsic disorder-based allostery.
The cooperativity of matrix with other inciting stimuli (growth factors, hypoxia and strain) associated with bladder obstruction was also examined.
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