Sentence examples for binding contacts with the from inspiring English sources

Fluoroquinolone derivatives having positively charged or aromatic moieties extended from the N-1 position were designed to probe for binding contacts with the phosphotyrosine residue in ternary complex.

However, other binding contacts with the enzyme or DNA substrate can mediate drug binding in a manner that is not optimal for inducing DNA cleavage.

3. Sorting out the wedding venue With some places costing up to £10,000 to hire for the big day, you need to make sure you have a legally binding contact with the venue or supplier so that they and you know exactly what is being provided.

The poses were then overlaid and examined for differences in the relative orientations of functional groups and for binding contacts with DNA and protein (see Supporting Information Figures S7, S8, and Table S2 for the 20 docked poses).

The results support a model for naïve antigen recognition in which large Tyr side-chains establish binding contacts with antigen, and small Ser and Ala side-chains serve as auxiliaries that help to position Tyr in favorable binding conformations.

M9 is a bipartite PY-NLS whose three-dimensional structure and binding contacts with TPNO-1 are well characterized.

Thus, the C-7 aminomethyl pyrrolidine substituent appeared to afford an additional binding contact with GyrB.

Consistent with the greater salt dependence, mutation of charged residues located outside the active site face affects ribosome binding but not SRL binding, implicating additional contacts with the ribosome or long-range tertiary interactions.

Most sequence-specific DNA binding proteins contact with the major groove of double stranded DNA in the B conformation [19], and some TFs are shown to bind DNA in a double-strand manner according to their crystal structures [20].

The 3,4,5-triacetyloxy-6- acetyloxymethyl 3,4,5-triacetyloxy-6- acetyloxymethyl 3,4,5-triacetyloxy-6- acetyloxymethyl 3,4,5-triacetyloxy-6- acetyloxymethylnd with two important residues of TR, His461′ and Glu466′, belonging to the second subunithiosugardiser, which activate Cys52 similarly to serine and cysteine proteases during trypanothione reduction (Fig.  4bound

While the deletion of the entire C-terminal HSS domain decreased the affinity of ISWI for DNA and nucleosomes, compromising mutations of DNA-interacting residues of the SLIDE domain had no effect on the affinity for nucleosome binding but did alter contacts with the flanking DNA.