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Striking distortion of streptavidin's binding contacts was found for these complexes.
Fluoroquinolone derivatives having positively charged or aromatic moieties extended from the N-1 position were designed to probe for binding contacts with the phosphotyrosine residue in ternary complex.
The results support a model for naïve antigen recognition in which large Tyr side-chains establish binding contacts with antigen, and small Ser and Ala side-chains serve as auxiliaries that help to position Tyr in favorable binding conformations.
54.8% native binding contacts and 79.2% helical content are remained.
Furthermore, the average structures of two transition states include native binding contacts.
There are 54.8% native binding contacts and 62.5% helical content remaining.
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3. Sorting out the wedding venue With some places costing up to £10,000 to hire for the big day, you need to make sure you have a legally binding contact with the venue or supplier so that they and you know exactly what is being provided.
6) At the second half time of unbinding, there are 53.7% native hydrophobic contacts and one native binding contact remaining.
The involvement of one more residue, in addition to Lys100 from the β3-strand, for the coordination of the β-phosphate comprises a novel binding contact never before seen in other kinases complexed with ATP.
Thus, the C-7 aminomethyl pyrrolidine substituent appeared to afford an additional binding contact with GyrB.
TRBP-RBD2 exhibits a binding (contact) area to minor groove II that is similar for all three duplexes.
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