Sentence examples for binding consistent with the from inspiring English sources

These results indicate that Ser214, together with the adjacent dicysteine motif C212/213, are equally essential in mediating the arsenic-PML binding, consistent with the data that S214L mutant is resistant to AS2O3-induced degradation.

The substantial conformational changes in the B′ helix and F G loop regions are induced upon ligand binding, consistent with the membrane nature of the protein and its substrate.

The pH dependence of steady state kinetic parameters indicate that ionizable groups with basic pKs may be involved in substrate binding, consistent with the observation of Lys223 at the enzyme active site in the recently determined 3D structure [B. DeLaBarre, P.R. Thompson, G.D. Wright, A.M. Berghuis, Nat. Struct. Biol. 7 (2000) 238–244].

The data show precursor binding to the RKIP pocket is not sufficient to interfere with Raf binding, consistent with the observed MAPK signaling in locostatin-treated cells.

Heparin also blocked wild-type MuHV-4 much better than the gp150 knockout for GAG+ CHO cell infection and binding, consistent with the antibody blockade differences in Fig. 6.

For the Herceptin interaction, the calculated and the observed buried ΔAnp in the crystal structure match closely (ΔΔAnp = 30 Å2, 3% of the observed ΔAnp), indicating minimal effect of the molecular rearrangements upon binding, consistent with the small differences between the free and bound structures of Herceptin and HER2 [24], [24] (Figure S2).

For S229W, the number of waters significantly changes from 132 to 54, a dramatic decrease with more than half of the water molecules squeezed out during DNA binding, consistent with recognition in the minor groove.

Substitution of Met1238 with alanine in DMEΔNΔIDR1 abrogated 5mC excision activity and had no effect on DNA binding, consistent with results from the corresponding residue (Met905) in ROS1.

Tumors from 4 different control mice showed patchy regions of high EF5 binding, consistent with heterogeneous binding and the presence of markedly hypoxic tumor regions (panels i-iv).

The des-amino ethidium analog exhibits fluorescence quenching upon binding, consistent with less efficient quenching of the chromophore through interactions with solvent than within the intercalation site.

The blockage of the substrate binding groove, along with compromised Zn2+ binding, are consistent with the lack of inhibitor binding observed suggested by the insignificant Δ Tm in the presence and absence of inhibitor M344 (Table 1 ).