Sentence examples for binding conformations to which from inspiring English sources
The cooperative effects observed above at the wild-type β1-adrenoceptor clearly highlight the presence of 2 distinct binding conformations to which β-adrenoceptor ligands can bind.
The significant difference between the wide and common binding conformations is in which amino acid residues are involved in the interaction and not in how decoron curvature changes to accommodate a tightly curved small fibril.
Indeed, the BODIPY-TMR-CGP dissociation rate was enhanced by 100 nM CGP 12177 and propranolol (and concentrations above), clearly highlighting the presence of a secondary topographically distinct β1-adrenoceptor binding conformation through which CGP 12177 and propranolol exert negative cooperative effects on the primary high-affinity β1-adrenoceptor conformation.
This form was converted upon stimulation into a binding conformation, which we called open-CD3.
PCBs can act on the RyR by stabilizing a high-affinity binding conformation, which results in increased intracellular calcium concentrations (Wong et al. 1997).
Computational studies revealed that 33 has a very stable binding conformation due to intramolecular hydrogen bonds, which cannot be formed with l-Phe in the P3 position.
The AFM images revealed significant changes in the protease protein domain conformation upon binding to collagen which are postulated to be associated with further deformation of the collagen triple-helical structure to gelatin-like morphologies.
There are two possible causes for this change in binding conformations (from linear to curved).
The assay indicated that the non-stimulated TCR complex was in a non-binding conformation, which we called closed-CD3 [33].
To further explore the binding mechanisms of these new inhibitors, we determined the X-ray structures of the complexes of FABP4-9 and FABP4-10, which revealed similar binding conformations of the two compounds.
